POLYMER GENOMICS
Epigenetic clocks·6 clocks · cross-comparison
§ CLOCKS · 6 epigenetic clocks · probe-level anatomy

Epigenetic clocks

Probe-level anatomy and cross-comparison of canonical DNAm clocks — Horvath, Hannum, PhenoAge, GrimAge — plus DunedinPACE and the Polymer in-house Retro-Age (built on TE/ERV-overlapping probes). Click any card to inspect its anatomy; scroll for cross-clock overlap and the age calculator.

§01Clocks6 clocks · 2,388 total probes
§02Clock anatomySelected: Horvath
HorvathHorvath, Genome Biol.RMSE ± 3.6 yr
Probes353
Tissuepan-tissue
Typechronological
Hyper / hypo56 / 44
Top weighted probes
ProbePositionGeneCoefficientMean β
cg16867657chr6:11,044,634ELOVL2+0.1420.421
cg22454769chr16:88,536,312FHL2+0.1180.388
cg14361627chr12:53,996,447KLF14-0.1080.412
cg06419846chr7:151,555,117PRKAG2+0.0980.296
cg17861230chr1:207,073,466PGLYRP4-0.0870.521
§03Cross-clock probe overlap% of smaller set shared
HorvathHannumPhenoAgGrimAgeRetro-ADunedinHorvathHannumPhenoAgeGrimAgeRetro-AgeDunedinPA10028169412281002214719162210031823914311001117478111005121923175100% of probes shared (smaller set / both)
§04Age calculatorAcceleration vs chronological
Chronological age45 yr
Horvath
46.9 yr+1.9
Hannum
45.0 yr-0.0
PhenoAge
43.9 yr-1.1
GrimAge
40.6 yr-4.4
Retro-Age
42.1 yr-2.9
DunedinPACE
1.04 yr/yr+0.04
Bar shows acceleration (predicted − chronological). Hyper-methylated probes drive higher predictions.