HLA Allele Biophysics

Material-channel analysis of 0 HLA alleles from IPD-IMGT/HLA. Non-coding biophysics (introns, UTRs) capture the hidden layer of expression-relevant variation that protein-level matching misses.Bettens et al. 2022 — non-coding cis-eQTLs explain 13-50% of HLA class I expression variance.