HLA·6 transplant loci · biophysics divergence

§ HLA · 6 transplant loci · 32,867 named alleles

HLA biophysics

Allele-level biophysics for transplant loci. Non-coding divergence (NCDS), expression tier inference, and pairwise comparison at base-pair resolution. Coding-identity-matched alleles can still differ markedly in non-coding regions — that signal is what Polymer surfaces.

§01LociSelected: HLA-B · class I

§02Alleles9 representative · sorted by global frequency

Allele	IMGT name	Population	Expression	Coding ID	NCDS	Notable
AB*07:02	HLA-B*07:02:01:01	eur · 11.4 %	HIGH	100.0 %	0.000	—
BB*08:01	HLA-B*08:01:01:01	eur · 9.7 %	MED	98.7 %	0.062	celiac
B*44:02	HLA-B*44:02:01:01	eur · 9.1 %	HIGH	98.5 %	0.067	—
B*35:01	HLA-B*35:01:01:01	global · 7.4 %	MED	97.9 %	0.091	—
B*15:01	HLA-B*15:01:01:01	global · 5.8 %	HIGH	98.3 %	0.078	—
B*58:01	HLA-B*58:01:01:01	eas · 5.5 %	LOW	97.1 %	0.121	allopurinol SCAR
B*51:01	HLA-B*51:01:01:01	global · 5.2 %	MED	97.4 %	0.114	Behçet
B*27:05	HLA-B*27:05:02:01	eur · 4.6 %	HIGH	98.1 %	0.084	ankylosing spondylitis
B*57:01	HLA-B*57:01:01:01	eur · 3.9 %	HIGH	97.6 %	0.103	HIV control · abacavir HSR

§03Pairwise non-coding divergencebiophysics signature across gene span

Pairwise comparison

AB*07:02

BB*08:01

Δ = 0.402

A · B*07:02B · B*08:01|A − B|

§04Locus-wide divergence distributionall pairs at HLA-B