Transposome·5.6M TEs · 4 superfamilies

§ TRANSPOSOME · 3.8M elements · 45 % of the genome

Transposome

Transposable elements with evolutionary age, reactivation propensity, and EPIC v2 probe overlap. Click any superfamily card to filter the subfamily table; scroll for the genome-wide age distribution and the top reactivation-risk loci.

§01Superfamiliesclick to filter

§02Subfamily breakdown17 subfamilies

Family	Blurb	Copies	Mean age	⟨β⟩	EPIC probes	Awakening
AluYSINE	Most recent Alu lineage; some active copies	78,200	6 MYA	0.71	28,412	0.72
AluSSINE	Older Alu lineage, broadly distributed	663,000	30 MYA	0.81	184,200	0.24
AluJSINE	Most ancient Alu lineage	336,000	65 MYA	0.85	71,344	0.08
MIRSINE	Mammalian-wide interspersed repeat	595,000	130 MYA	0.86	88,711	0.03
L1HSLINE	Human-specific L1 · only active retrotransposon	4,842	4 MYA	0.68	3,724	0.91
L1PA2LINE	Hominoid-specific	6,117	8 MYA	0.73	4,980	0.62
L1PA3LINE	Hominoid	12,488	13 MYA	0.76	9,188	0.41
L1PA4-7LINE	Older L1 lineages	52,300	26 MYA	0.82	27,900	0.18
L2LINE	Ancient LINE-2	466,000	170 MYA	0.87	71,440	0.02
HERV-KLTR	Youngest ERV family; some intact ORFs	2,345	30 MYA	0.69	1,872	0.84
HERV-HLTR	Pluripotency-associated; active in stem cells	1,028	30 MYA	0.74	922	0.58
HERV-WLTR	Syncytin-1; placental fusion	678	40 MYA	0.71	611	0.49
HERV-ELTR	Tissue-specific expression	1,415	50 MYA	0.77	988	0.32
MaLRLTR	Mammalian-apparent LTR retrotransposons	173,800	90 MYA	0.83	38,240	0.07
hATDNA	Charlie family · ancient, inactive	95,200	110 MYA	0.85	22,341	0.02
TiggerDNA	pogo-like · inactive	72,811	95 MYA	0.84	19,472	0.03
MarinerDNA	Tc1/mariner · inactive	24,113	80 MYA	0.83	6,120	0.04

§03Genome-wide age distribution0 → 200 MYA · bimodal: recent (L1HS, AluY, HERV-K) + ancient (L2, MIR)

§04Reactivation risk · top locihypo-methylated · young · context-flagged

Family	Position	Length	Age	β	Context	Awakening
L1HS	chr1:92,412,847	6,088 bp	1.8 MYA	0.61	intergenic · TET2-bound	0.94
HERV-K	chr5:29,124,500	9,142 bp	5.0 MYA	0.58	KRAB-ZF dependency	0.91
L1HS	chr8:105,344,017	6,119 bp	2.4 MYA	0.64	antisense to oncogene	0.89
HERV-K	chr19:47,628,771	8,983 bp	6.1 MYA	0.62	enhancer overlap	0.87
L1HS	chr11:8,842,004	5,988 bp	3.0 MYA	0.65	replication-late	0.84
AluY	chrX:53,991,447	312 bp	5.5 MYA	0.66	X-inactivation escape	0.81
HERV-H	chr2:127,842,011	5,724 bp	32.0 MYA	0.62	pluripotency lncRNA	0.78
L1PA2	chr17:43,544,021	6,017 bp	8.2 MYA	0.68	BRCA1 5' UTR neighbor	0.75
HERV-K	chr11:102,716,409	9,018 bp	6.8 MYA	0.64	cancer-up-regulated	0.74
L1HS	chr14:72,184,512	6,142 bp	3.8 MYA	0.69	somatic-mosaicism hot	0.71